Chiefs running back Isiah Pacheco has officially been ruled out for Sunday’s game against the Bills.

During Wednesday's press conference, Kansas City Chiefs HC Andy Reid discussed plans at running back after Isiah Pacheco's injury | @EdEastonJr

Coach Andy Reid said Friday that Pacheco (knee) is unlikely to play Sunday at Buffalo, Matt Derrick of ChiefsDigest.com reports.

Chiefs running back Isiah Pacheco is reportedly week-to-week with an MCL sprain suffered during Monday night's victory over the Commanders.

Kansas City Chiefs running back Isiah Pacheco and Chicago Bears running back D'Andre Swift have both been ruled out for Week 9. That paves the way for bigger workloads for rookie backs Kyle Monangai and Brashard Smith.

Kansas City Chiefs running back Isiah Pacheco, a two-time Super Bowl champion, honors his late siblings, Travoise and Celeste, who died tragically wit

The Chiefs’ Thursday practice report did not bring good news for Isiah Pacheco’s availability for Sunday. He remained out of practice with an MCL sprain in his knee. Coach Andy Reid said Wednesday that he does not expect Pacheco’s injury to keep him out long term. It could keep him out of Sunday’s game against the Bills, though.

The Kansas City Chiefs' 2025 NFL trade deadline priorities might have changed over the past week, with the Tuesday, Nov. 4 deadline rapidly approaching. There was a clear need at the interior defensive line position after the injury to Omarr Norman-Lott.