Head coach Jeff Brohm revealed after the Cardinals' victory win over the Hokies that star running back Isaac Brown "might be out for a little while" after suffering a leg injury late in the game. "He might be out for a little while," Brohm said. "Unfortunately, he hurt his leg there, and we're anticipating him being out for a while."

South Carolina State Bulldogs at Louisville Cardinals Louisville, Kentucky; Monday, 9 p.m. EST BETMGM SPORTSBOOK LINE: Cardinals -32.5; over/under is 154.5 BOTTOM LINE: No. 11 Louisville hosts South Carolina State in the season opener.

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

It's the third championship for Smith, who also won it with the Dodgers in 2020 on top of last season. Smith is the only Louisville alumni to win multiple championships, and just one of two to win a World Series after Adam Duvall did so with the Atlanta Braves in 2021.

Louisville basketball forward Kasean Pryor was ruled out of the No. 10 Cardinals' exhibition against Bucknell at the KFC Yum! Center. Pryor hasn't seen game action since tearing the ACL in his left knee on Nov. 29, 2024. Pat Kelsey has said multiple times ...

Louisville basketball forward Kasean Pryor was ruled out of the No. 10 Cardinals' exhibition against No. 19 Kansas at the KFC Yum! Center. Pryor hasn't seen game action since tearing the ACL in his left knee on Nov. 29, 2024. Pat Kelsey has said multiple ...

Louisville looked like far from a polished product in their previous exhibition matchup against Kansas. For starters, they connected on just 33.3 percent of their total field goal attempts, while allowing the Jayhawks to shoot at a 50.0 percent clip Additionally, the Cardinals turned it over 20 times, and allowed 34 points int he paint.