For about 30 minutes on Saturday afternoon, it looked like the Virginia Tech Hokies were about to win their second game in a row and move to 3-2 in ACC play. Unfortunately, a lopsided third quarter changed everything, and the No. 16 Louisville Cardinals (7-1, 4-1) came from behind to defeat the Hokies 28-16 (3-6, 2-3).

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

There were also gaffes. After a Donavon Greene third-down drop on a deep ball, Louisville wideout Caullin Lacy fielded the ball on his own 32. He made his way down to the Hokies' five-yard line. Two plays later, tailback Keyjuan Brown punched it in a two-yard gain that gave Louisvill a lead it would never yield.

Who will miss the Louisville Cardinals' Week 10 ACC college football game vs. Virginia Tech? Here's the latest Louisville football injury report.

Keyjuan Brown scored twice in the second half to lead the No. 16 Louisville Cardinals, who rallied for a 28-16 victory over the Virginia Tech Hokies Saturday in Blacksburg, Va.