Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

San Francisco 49ers QB Mac Jones fired a strike to WR Kendrick Bourne, moving the chains with an 18-yard gain vs. the Texans.

The Texans lost to the Seattle Seahawks 27-19 on Monday night even though Anderson scored the first touchdown of his NFL career. Anderson had a strip-sack of quarterback Sam Darnold and recovered the fumble in the end zone.

The similarities are obvious. Daniel Jones, Mayfield, Darnold and Mac Jones were high- or mid-first-rounders, while Smith was an early second-rounder. League executives agreed each player has always possessed the physical skills to start in the NFL, which was indicative of their draft stock.

San Francisco 49ers coach Kyle Shanahan provided an update on quarterback Brock Purdy's injury, while Mac Jones suffered a knee contusion.

San Francisco 49ers tight end Jake Tonges catches a 2-yard touchdown pass on a crossing route from quarterback Mac Jones against the Houston Texans.