In a chemistry version of whipping up a delicious dinner from pantry staples, researchers in Korea have found a recipe for ...
Takeaway 3: The Alcohol-to-Amide Shortcut The team extended their logic to create a "one-pot" enzymatic cascade that starts from broadly available aliphatic alcohols. This chemoenzymatic strategy is ...
(4) Carboxylic acids and amines themselves do not react to form amides. Instead, a process activates the carboxylic acid, making it susceptible to amide formation. I don't get paid enough to broach ...
Amide bonds are among the most ubiquitous linkages in natural products, pharmaceuticals and polymers, yet their inherent resonance stabilisation renders them remarkably inert to conventional reaction ...
A team at UNC-Chapel Hill has developed a new process for synthesizing amides in a 100% atom-economical, sustainable fashion using Earth-abundant, environmentally friendly cobalt. UNC-Chapel Hill ...
Conventional methods for N-acylation of heterocyclic, nitrogen-containing compounds are notoriously inefficient, producing low yields and often involving preactivated reagents, strong metal bases and ...
Extending or trimming the length of a drug molecule’s carbon backbone by just a couple of atoms can significantly alter its activity, even if nothing else in the structure changes. So reactions that ...
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