Voltage‐gated calcium channels are integral transmembrane proteins that convert membrane depolarisation into a multitude of intracellular responses, ranging from muscle contraction and ...

The study also sheds light on evolutionary and physiological questions. RyR1 channels are arranged in skeletal muscle in a pattern where only half are physically coupled to voltage sensors, prompting ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Large-conductance calcium-activated potassium (BK) channels are critical determinants of smooth muscle function by mediating rapid feedback between intracellular calcium levels and membrane potential.

Scientists have revealed how the electrical patterns formed within an embryo initiate a cascade of molecular changes that culminate in the development of cartilage and bone. Prior studies have shown ...

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Benidipine calcium channel blocker ...