The Tennessee Titans have a tough matchup with the Indianapolis Colts this week, and here are five matchups that could determine the outcome.

The Indianapolis Colts look like one of the best teams in the NFL, and the Tennessee Titans look like one of the worst. That just about sums up the tale of the tape between these two AFC South rivals.

Few people, if any, thought the Indianapolis Colts would hold the NFL’s best record going into a Week 8 home game with the Tennessee Titans.

Colts offense: overall (2), rush (7), pass (5), scoring (1). Colts defense: overall (22), rush (6), pass (29), scoring (T-8).

Questions loom about WR Calvin Ridley, DT Jeffery Simmons and CB L'Jarius Sneed as the Tennessee Titans ready themselves for the Indianapolis Colts.

The Tennessee Titans (1-6) are back on the road this Sunday when they face the Indianapolis Colts (6-1) at Lucas Oil Stadium in Indianapolis, Indiana, at 3:25 p.m. CDT. Opening the week, the Titans were listed as 14-point underdogs, and as of this writing, that is where the spread currently sits.

Nobody expected the Indianapolis Colts to contend for a Super Bowl as an 80-to-1 longshot entering Week 1. However, that number is down to 12-to-1 at FanDuel following a surprising 6-1 start for Indianapolis.

The Indianapolis Colts' offense is not only one of the best in the NFL this season, but it is also playing at a level that puts them in the conversation as one of the best in NFL history. In Week 7, they improved to 6-1 on the year with a big road win vs.

Pittsburgh Steelers quarterback Aaron Rodgers will get his start against his former team on Sunday Night Football. There will be shock value. Rodgers will be in a throwback Steele

Pregame analysis and predictions of the Tennessee Titans vs. Indianapolis Colts NFL game to be played on October 26, 2025 on ESPN.