Nearly 1 in 7 adults in the United States lives with chronic kidney disease, a condition that often advances quietly until ...

The neurodevelomental disease Rett syndrome is usually caused by mutations in a gene called MECP2, which is located on the X chromosome. Patients lose coordination, mobility, and their ability to ...

In humans, hundreds of proteins interact in a complex network dubbed the interactome. Those interactions are further complicated when disease-causing mutations are introduced into genes that code for ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk ...

It might seem counter-intuitive to anyone awed by the record-beating achievements of elite athletes like Usain Bolt, Femke Bol or Armand Duplantis, but genetic mutations are making humans less fit ...

Figure 4: Loss of p53 predisposes to mammary tumors in mice and in women, but penetrance varies among individuals. The prevalence of TP53 mutations in nearly all tumors emphasizes its role as a ...