Nature

Defects in DNA damage signaling and cell cycle checkpoints in a mouse model of Rhno1 deletion

In response to DNA damage or DNA replication stress, cells activate signaling pathways dependent on the kinase, ATR (Ataxia Telangiectasia and Rad3-Related). ATR signaling leads to induction of cell ...
Medical Xpress

TIE2 protein emerges as potential drug target to prevent development of dangerous blood vessel defects in brain

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a cell surface receptor protein called TIE2 as the missing link between two key signaling pathways that ...
Nature

Signaling pathways and targeted therapy for pulmonary hypertension

Pulmonary hypertension (PH) is a global health issue characterized by high mortality. The main targets for current therapies in PH focus on the prostacyclin, nitric oxide, and endothelin pathways.
EurekAlert!

Researchers identify new drug target to prevent development of dangerous blood vessel defects in brain

Microscopic images of cranial blood vessels show the growth of mulberry-shaped CCMs over a 21 day period in control mice (top two rows). This growth is prevented by treatment with the TIE2 inhibitor ...
GEN

Blocking TIE2 Protein May Prevent Blood Vessel Defects in the Brain

Scientists from the Perelman School of Medicine at the University of Pennsylvania and their colleagues have identified a cell surface receptor protein called TIE2 as a critical component of two key ...
Nanowerk

Signal Transduction: Pathways, Mechanisms, and Therapeutic Targets

Signal transduction The cellular process that converts a signal, such as a hormone, growth factor, neurotransmitter, cytokine, mechanical force, or environmental cue, into biochemical changes inside ...