JSTOR Daily

On the Proton Transfer Behavior of the Primary Oxidation Product in Irradiated DNA

Results are surveyed from investigations of six adenine and six guanine crystal systems X-irradiated and studied at temperatures near that of liquid helium (T < 10 K). Basic conclusions from the ...
JSTOR Daily

Initial Yields of DNA Double-Strand Breaks and DNA Fragmentation Patterns Depend on Linear Energy Transfer in Tobacco BY-2 Protoplasts Irradiated with Helium, Carbon and Neon Ions

The ability of ion beams to kill or mutate plant cells is known to depend on the linear energy transfer (LET) of the ions, although the mechanism of damage is poorly understood. In this study, DNA ...
EurekAlert!

Sirtuin 6 activation rescues the age-related decline in DNA damage repair in chondrocytes

“[...] the biological mechanisms linking aging and osteoarthritis prevalence remain largely unknown.” “In this study, we use irradiation as an acute model of ...
News Medical

Sirtuin 6: A potential savior for aging cartilage and osteoarthritis

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the ...
ascopubs.org

Preclinical efficacy data of MGN1601, a tumor vaccine comprising 4-fold gene-modified and irradiated allogeneic tumor cells in combination with a DNA-based immunomodulator for ...

ERCC1 polymorphisms in patients with advanced bladder cancer treated with platinum-based chemotherapy. Background: MGN1601 is a cell-based tumor vaccine for the treatment of mRCC. MGN1601 consists of ...