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Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations, analysis suggests

Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited mutations in the BRCA1 or BRCA2 genes, according to the results of a matched ...

BRAF gene mutation leads to different therapeutic responses in melanoma and colorectal cancer

A review article led by researchers from the B·ARGO group at the Germans Trias i Pujol Research Institute (IGTP) and from the ...
EurekAlert!

Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML

Disruptions in transcriptional regulation during hematopoiesis can lead to abnormal hematopoietic differentiation and the development of leukemia. Understanding the underlying mechanisms of disease ...
ascopubs.org

Analysis of ATM germline mutations in solid tumors from Chinese patients.

Twenty-one gene recurrence scores in individuals with breast cancer associated with CHEK2 and ATM germline pathogenic variants. Characteristics and clinical outcome of BRCA germline mutation carriers ...
eLife

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...
Oncology Nurse Advisor

Use of Tanning Beds More Than Doubles Melanoma Risk

Tanning bed usage was associated with an increased risk of melanoma, at an odds ratio of 2.85, while further analysis revealed a dose–response relationship between the number of tanning bed exposures ...
Santé log

Landmark Study Shows Combination of Castle Biosciences' DecisionDx®-UM and PRAME Outperforms Gene Mutation Analysis in Predicting Survival Outcomes in Uveal Melanoma

Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced new data from the largest prospective, multicenter study to date ...

Aging Sperm Are Mutating Faster Than Scientists Expected

The analysis revealed that about 2 per cent of sperm from men in their early 30s contained disease-causing mutations. That ...
Morning Overview on MSN

This rare mutation destroys brain cells, scientists found the cause

Scientists have traced a devastating pattern of brain cell loss in a handful of families to a single, ultra-rare mutation ...