Osteoarthritis pain arises from a dynamic interplay of peripheral and central processes that amplify nociceptive signalling beyond the extent of joint damage alone. At the periphery, local ...

Pain sensitization has a major impact on the perception of pain, affecting both physical function and quality of life (QoL), in patients with knee osteoarthritis (OA), according to the results of a ...

The burden of chronic pain. Source: GoodIdeas / Shutterstock Nerve sensitization often contributes to chronic pain states, such as back pain, migraines, and irritable bowel. Sensitization is an ...

Two women in the emergency room sit across from each other, their eyes red and welling with tears. Watching the minute hand of the clock slowly tick by, they eagerly await their turn to be seen. That ...

Central sensitization syndrome can cause the brain to overreact to harmless stimulation, leading to intense pain feelings. Typically, the CNS sends sensory signals to the brain. The brain accurately ...