While anti-VEGF therapies remain the current standard of care, many DME patients experience suboptimal responses due to ...

Leishmaniasis belongs to the class of neglected tropical diseases (NTDs) that particularly affect people in the poorest ...

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...

Protein kinase D (PKD) comprises a family of serine/threonine kinases that are integral to cellular signal transduction. These enzymes regulate key processes such as cell proliferation, survival, ...

Activating lysosome biogenesis helps alleviate cellular senescence in progeria. Hutchinson-Gilford progeria syndrome (HGPS) ...

Summary: A new study reveals that the brain uses two distinct neural pathways to regulate sugar and fat intake. In mice, glucoprivation—a drop in blood sugar levels—activates separate circuits in the ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

Merck KGaA has reported proteolysis targeting chimera (PROTACs) comprising an E3 ubiquitin ligase-binding moiety covalently linked to mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; ...

The EMA says a study did not show clinical benefit, while Sanofi says it will continue to work closely with the regulator to bring the treatment to patients.