Leishmaniasis belongs to the class of neglected tropical diseases (NTDs) that particularly affect people in the poorest ...
Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...
While anti-VEGF therapies remain the current standard of care, many DME patients experience suboptimal responses due to ...
Protein kinase D (PKD) comprises a family of serine/threonine kinases that are integral to cellular signal transduction. These enzymes regulate key processes such as cell proliferation, survival, ...
NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...
Merck KGaA has reported proteolysis targeting chimera (PROTACs) comprising an E3 ubiquitin ligase-binding moiety covalently linked to mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; ...
Activating lysosome biogenesis helps alleviate cellular senescence in progeria. Hutchinson-Gilford progeria syndrome (HGPS) ...
Google AI Breakthrough Highlights Silmitasertib (CX-4945) as a Novel Pathway in Cancer Immunotherapy
Silmitasertib (CX-4945) is Senhwa's first-in-class CK2 inhibitor, currently under clinical development across multiple cancer indications. To date, the compound has been administered to hundreds of ...
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