Expert Rev Cardiovasc Ther. 2008;6(5):601-608. The first Phase III clinical trial to study tolvaptan was the Study of Ascending Levels of Tolvaptan in Hyponatremia (SALT)-1/-2, which consisted of two ...
Loop diuretics relieve congestion in patients with heart failure but are associated with neurohormonal activation and unfavorable outcomes at higher doses. Vasopressin receptor antagonists -- ...
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A study assessing tolvaptan efficacy in patients 35 years or younger found a 40% difference in eGFR decline compared with standard care. Tolvaptan initiation in adults aged 35 years or younger with ...
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