As spindly, elongated cells, neurons must be able to transport proteins and receptors between distant sites in their cell bodies and axons to function properly. A new imaging study by researchers at ...

Adenovirus serotype 5 (Ad5) is widely used in the development of gene therapy protocols. However, current gene therapy strategies involving brain are mostly based on intra-cranial injection. A major ...

A cellular trafficking system called transcytosis may actually do most of the work in controlling the permeability of the barrier between the blood and the central nervous system, according to new ...

All cells, whether big or small, short or long, rely on proteins to function properly. In most cells, transporting these proteins is relatively simple. Neurons in the brain, however, face a ...

Transferrin receptor (TfR)-mediated transcytosis is a receptor-mediated mechanism for drug delivery to the brain or other tissues, where, after the antibody binds to transferrin, the therapeutic agent ...