Image Caption: TME and tumor blood vessels. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human ...

Members of the Ren Lab have investigated the effects of a new pathway, the LPA/PKD-1 -CD36 signaling axis, on tumor angiogenesis and breast cancer stem cells, a subpopulation of breast cancer cells ...

A recent paper in Nature Cancer outlines a novel strategy for overcoming barriers to CAR T-cell therapy in glioblastoma by pretreating the vascular microenvironment. Every day, chimeric antigen ...

The labyrinth of jumbled blood vessels in the tumor microenvironment remains one of the toughest blockades for cellular therapies to penetrate and treat solid tumors. Now, in a new study published ...

Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced ...

BUFFALO, N.Y. -- Gail Seigel, PhD, research assistant professor in the University at Buffalo Department of Physiology and Biophysics, will be part of a group of researchers taking part in the new ...

Penn Medicine researchers use mice experiments to find a potential solution to the challenge of delivering CAR T cell treatments to solid tumors in glioblastoma. The wonders of chimeric antigen ...

A joint research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and Queen Mary University of London (QMUL) has discovered the molecular mechanisms of how pathological ...