San Francisco 49ers running back Christian McCaffrey is a strong favorite for the Comeback Player of the Year award.

Christian McCaffrey speaks out on the San Francisco 49ers’ mounting injury challenges after losing to the Houston Texans.

HOUSTON – Christian McCaffrey was bottled up, surrounded by the Texans’ relentless defense armed with motivation and the knowledge of just how pivotal the star running back is to the San Francisco 49ers’ offense. McCaffrey didn’t have much, if any, breathing room to operate during the Texans’ 26-15 win Sunday at NRG Stadium.

The San Francisco 49ers have a chance to raise their record to a surprising 6-2 going up against a struggling Texans team, but can the Niners get going against Houston's tough defense?

San Francisco 49ers running back Christian McCaffrey became the fifth running back in NFL history, joining three Hall of Famers, to hit new milestone.

San Francisco 49ers star running back Christian McCaffrey dominated the Atlanta Falcons' defense while the NFC South team's offense had no answers.

This article was originally published on www.si.com/nfl/49ers as 49ers RB Christian McCaffrey Earns Major NFL Award. Christian McCaffrey exploded in the San Francisco 49ers' win against the Atlanta Falcons.

Learn more about for Christian McCaffrey's prop betting lines, stats and more before his San Francisco 49ers play against the Houston Texans in a Week

The problem has been kickoffs. Pineiro followed his third-quarter field goal with a line-drive kickoff the Falcons returned 45 yards to the 49ers’ 48-yard line. The play gave Atlanta momentum, and the Falcons converted it into a 10-yard catch-and-run touchdown to Robinson to close San Francisco’s lead to 13-10.

Oct 19, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) celebrates after a touchdown during the second quarter against the Atlanta Falcons at Levi's Stadium. Mandatory Credit: Kyle Terada-Imagn Images / Darren Yamashita-Imagn Images

San Francisco 49ers running back Christian McCaffrey was great against the Falcons on Sunday and has been named the Offensive Player of the Week.

San Francisco 49ers running back Christian McCaffrey leads the NFL with 981 scrimmage yards (516 receiving, 465 rushing) this season