The development of mRNA vaccines, "bioorthogonal chemistry" or even artificial skin are some of the discoveries tipped for the Nobel Chemistry Prize announced Wednesday, which experts see as a toss-up ...

As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: soreness, redness and a day or two of malaise. But what if mRNA vaccines ...

The success of mRNA vaccines has been realised, in part, by advances in manufacturing that enabled billions of doses to be produced at sufficient quality and safety. However, mRNA vaccines must be ...

A combination mRNA cancer vaccine from BioNTech and Regeneron may be one step closer to actualization based on initial Phase 2 results unveiled Tuesday. The mRNA-based vaccine, BNT111, in combination ...

Despite the remarkable success of mRNA vaccines, improving the translational efficiency of mRNA therapeutics remains a critical challenge to their widespread clinical application. Here we ...

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network. The ...

Lipid nanoparticle (LNP) vehicles have been crucial to the success of the Pfizer-BioNTech and Moderna COVID-19 vaccines. Without these LNP vehicles, the vaccines’ mRNA payloads wouldn’t have survived ...

The incredible success of mRNA vaccines against COVID-19 has generated a surge of interest and investment in the development of this new therapeutic modality. Products based on mRNA have broad ...

Fig. 2 Examples of ionizable lipids, sterols, phospholipids, and PEG-lipids used in LNP formulations. Created with BioRender.com. Fig. 3 High-throughput screening of the 3-component ionizable ...

The messenger RNA (mRNA) COVID-19 vaccines were game changing during the course of the pandemic; now another benefit is emerging—the same vaccines are improving how long people with cancer survive ...

Primary endpoint met in a Phase 2 trial evaluating the investigational mRNA immunotherapy BNT111 in combination with the PD-1 checkpoint inhibitor cemiplimab Data demonstrated a statistically ...

Pieter Cullis, Drew Weissman and Katalin Kariko are thought to be among the favourites for the Nobel Chemistry Prize – Copyright AFP Nhac NGUYEN The development of ...