Jaxson Dart was supposed to lead the New York Giants back to relevance for the first time since the days of Eli Manning in his first full season as a starter.

Karolinska Institutet reports ROR1 inhibitor KAN571C wipes out double‑resistant MCL after ibrutinib/venetoclax, spotlighting a promising target. A small molecule inhibitor of ROR1, a receptor largely absent from normal adult tissue but overexpressed in mantle cell lymphoma (MCL),

Kyle Shanahan said Jake Tonges will undergo season-ending surgery to repair his torn MCL. Tonges went down with the injury in Week 1. He filled in for George Kittle admirably last year and was likely going to play a role in the offense for the first month of this season as Kittle got up to full speed.

Saints RB Alvin Kamara has "no limitations," was a full participant in practice and said his knee feels good just one month after spraining his MCL in practice.