Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...

From Santiago Ramón y Cajal’s hand came branches and whorls, spines and webs. Now-famous drawings by the neuroanatomist in the late 19th and early 20th centuries showed, for the first time, the ...

J.K. Rowling is not accepting Emma Watson’s olive branch. The Harry Potter author recently made it clear she is still at odds with one of the stars of the film franchise following comments the actress ...

What if a soft material could move on its own, guided not by electronics or motors, but by the kind of rudimentary chemical ...

It’s the second day of a shutdown of the federal government. We explain what’s happening. By Adam B. Kushner I’m the editor of this newsletter. For weeks, our D.C. reporters chronicled a slow-motion ...

Tim is an Australian Senior Editor based in Germany who has been passionate about video games since he first picked up a PlayStation 1 controller to play Crash Bandicoot as a kid. He started out with ...

“In what world is he the hero?” the tagline for “Peacemaker” Season 2 asks. The answer? Not a very good one. “Peacemaker” Season 2 follows John Cena’s titular vigilante as he retreats into a world ...

Minnesota Lynx forward Napheesa Collier unleashed a scathing assessment on the WNBA and Commissioner Cathy Engelbert on Tuesday, shaking up the league. Collier went scorched earth on Engelbert and the ...

If you have kids, you’ve probably heard them blurt out “6-7” recently, with emphasis on the seven. Something like six-seven. Gen Alpha are randomly repeating the numbers and laughing at the inside ...