NFL Week 3 score predictions, picks, betting odds for New York Giants vs Tennessee Titans game Sunday, Sept. 27, 2026. Who will win NFL Week 3 game?

There is little doubt that Jaxson Dart’s left knee injury has emerged as a major season-altering blow for the New York Giants. Dart suffered the injury on the opening drive of the Giants’ 28-6 loss to the Los Angeles Rams and is now facing the possibility of season-ending surgery.

A new report says that an MRI revealed more damage than expected in Dart's knee, and that none of his return timelines look "very good."

Here's a look at where the New York Giants sit in the NFL power rankings heading into Week 3.

The New York Giants' season is on the rocks, and if they wanted to start a sell-off, a trade of Kayvon Thibodeaux would be a great place to begin.

New York Giants quarterback Jameis Winston (19) and New York Giants running back Cam Skattebo (44) dance during warmups during a preseason opening game between the New York Giants and Minnesota Vikings on Saturday, Aug. 15, 2026, at MetLife Stadium in East Rutherford, NJ. Credit: USA TODAY Network via Reuters Connect (Reuters)

Safety Jevon Holland was the New York Giants' highest-graded player in a Week 2 loss to the Los Angeles Rams.

The Titans' matchup against the Giants in Week 3 features six intriguing storylines, including Brian Daboll's return to New York and more.

Panthers quarterback Bryce Young passed for 287 yards and three touchdowns, two of which went to tight end Darren Waller. Carolina forced five turnovers -- three interceptions and two fumbles -- as Atlanta had just 286 total yards of offense.