- Preclinical data identify SHP-1 as a downstream effector of GDF-15-mediated inhibition of T cell adhesion, further elucidating mechanistic details of GDF-15’s role in immunotherapy resistance. - ...
Cachexia is a common complication of cancer and is associated with an increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating cytokine, is elevated in cancer ...
First report to show link between GDF-15 and LFA-1/ICAM-1 cell adhesion axis in cancer, resulting in impaired infiltration of T cells into the tumor microenvironment First report to show link between ...
eGFRdiff and GDF-15 are independent predictors of chronic kidney disease progression and mortality in diabetes, highlighting their potential for risk stratification in clinical practice. Kidney ...
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