The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence ...

-30 percent of patients achieved a complete response after 4 weeks of dosing, 50 percent of which were IgE high (≥100 IU/ml) -41 percent of patients demonstrated a clinically meaningful response with ...

Sulfur-containing molecules such as glutathione, coenzyme A and the amino acids cysteine and methionine are essential for the maintenance of cellular redox balance, metabolic pathways, and enzyme ...

Monocyte to lymphocyte ratios and cancer-specific mortality for patients with renal cell carcinoma and inferior vena cava tumor thrombus. Peripheral blood cell counts as biomarkers of clinical benefit ...

SAN DIEGO--(BUSINESS WIRE)--Escient Pharmaceuticals, a clinical-stage drug development company advancing novel small molecule therapeutics for systemic neuro-immune disorders, today announced that the ...

In a recent study posted to the bioRxiv* preprint server, researchers cloned and functionally characterized the virus ribonucleic acid (RNA) sensor, retinoic acid-inducible gene-I (RIG-I), from the ...

Chronic urticaria is defined as wheals (hives), angioedema (swelling), or both that have been continuously or intermittently present for at least 6 weeks, 1,2 in contrast to acute urticaria, which is ...

The ability to control transgene expression, both spatially and temporally, is essential for studying model organisms. In Drosophila, spatial control is primarily provided by the GAL4/UAS system, ...

Sustained Hif1α (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient ...

Patients with von Hippel–Lindau (VHL) disease have a high incidence of renal cell carcinoma owing to VHL gene inactivation and constitutive activation of the transcription factor hypoxia-inducible ...