Hurricane Melissa is slamming eastern Cuba on Wednesday morning, Oct. 29, after hammering Jamaica on Tuesday and causing widespread damage.

The United Nations General Assembly overwhelmingly called for an end to a U.S. economic embargo on Cuba despite lobbying by Washington that included sharing an accusation that up to 5,000 Cubans are fighting alongside Russian forces in Ukraine.

After Melissa moves away from Jamaica, Cuba is next in line for the powerful hurricane’s fury. Landfall is expected very early Wednesday morning, likely a couple hours after midnight, but impacts have already begun.

The U.N. General Assembly has voted overwhelmingly to condemn the U.S. economic embargo of Cuba for a 33rd year.

Four-time Grammy Award winner Gloria Estefan rues Donald Trump’s America, saying some things are now akin to Fidel Castro’s Cuba. The “Rhythm is Gonna Get You” icon said she knows people who have been “taken away” as part of Trump’s immigration crackdown.

Sagua de Tánamo, a town in Holguín province, awoke to flooding of the Sagua River. In Contramaestre, a town in Santiago de Cuba province, Melissa’s strong winds uprooted trees and tore off sections of sidewalk.

Cuba’s president, President Miguel Díaz-Canel, warned residents to brace for a “very difficult night” as the island prepared for Hurricane Melissa to make landfall early Wednesday.

Parts of the Caribbean are conducting search and rescue operations and surveying the extensive destruction Hurricane Melissa brought to the region, leaving dozens of people dead. Melissa tore through the Caribbean as one of the most powerful storms in recorded history and made landfall in Jamaica on Tuesday as a deadly Category 5 hurricane.