A SpaceX Dragon capsule, riding atop one of the company’s Falcon 9 rockets, carried the four Crew-10 astronauts — NASA’s Anne McClain and Nichole Ayers, Takuya Onishi of the Japan Aerospace Exploration Agency,

The Crew-10 mission includes NASA astronauts Anne McClain and Nichole Ayers, as well as JAXA mission specialist Takuya Onishi and Roscosmos cosmonaut Kirill Peskov. The crew will spend several months aboard the ISS conducting experiments, research, and performing spacewalks.

After their flight was scrubbed on Wednesday, four astronauts successfully lifted off, which will allow two NASA astronauts to return to Earth after an unexpected extended stay in orbit.